가토의 두정골 결손부 모델에서 수산화인회석에 4-hexylresorcinol을 혼합하여 만든 인공합성골이식재의 골형성효과에 대한 연구
The Effect of a Hydroxyapatite and 4-hexylresorcinol Combination Graft on Bone Regeneration in the Rabbit Calvarial Defect Model
김민근, 박용태, 김성곤, 박영욱, 이석근, 채원식,
소속 상세정보
김민근 ( Kim Min-Geun ) - 강릉원주대학교 치과대학 구강악안면외과학교실
박용태 ( Park Yong-Tae ) - 강릉원주대학교 치과대학 구강악안면외과학교실
김성곤 ( Kim Seong-Gon ) - 강릉원주대학교 치과대학 구강악안면외과학교실
박영욱 ( Park Young-Wook ) - 강릉원주대학교 치과대학 구강악안면외과학교실
이석근 ( Lee Suk-Keun ) - 강릉원주대학교 치과대학 구강병리학교실
채원식 ( Choi Weon-Sik ) - 한국기초과학지원연구원 강릉센터
KMID : 0360120120340060377
Abstract
Purpose: The aim of this study was to evaluate the effect of 4-hexylresorcinol and hydroxyapatite combination graft on bone regeneration in the rabbit calvarial defect model.
Methods: Ten New Zealand white rabbits were used for this study. Bilateral round shaped defects (diameter: 8.0 mm) were created on the parietal bone. 4-hexylresorcinol and hydroxyapatite combination graft material was grafted into the right parietal bone defect area (experimental). The left bone defect area was not filled with anything (control). The animals were sacrificed at 4 weeks and 8 weeks after grafting. A micro-computerized tomography of each specimen was taken, and the specimens were stained for histological analysis.
Results: The average value of bone mineral density (BMD) and Bone volume (BV) was higher in the experimental group than in the control group at 4 weeks and 8 weeks after surgery. However, the difference was not statistically significant (P>0.05) at 8 weeks after grafting. The BMD and BV in the experimental group at 4 weeks after surgery was significantly higher than those in the control group (P<0.05).
Conclusion: 4-hexylresorcinol and hydroxyapatite combination graft material showed higher initial bone formation than the control, however, there was no difference at 8weeks after operation.
키워드
4-hexylresorcinol;Hydroxyapatite;Bone regeneration
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